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Keep an eye on Intently (1)pentobarbital will improve the stage or effect of clopidogrel by influencing hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital decreases levels of toremifene by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of. CYP3A4 inducers enhance level of toremifene metabolism, decreasing the r